Prime Video’s September 2025 slate brings a mix of new and returning titles, from The Runarounds, a coming-of-age rock band drama to the gorgeous Hotel Costiera, a high-stakes mystery in an Italian luxury hotel, starring Grey’s Anatomy alum Jesse Williams.
Gen V also makes a splashy Season 2 return with a new Dean in charge at Godolkin. Meawwhile, limited series The Girlfriend, starring Olivia Cooke and Robin Wright, makes us all feel uncomfortable, while YouTube’s Helluva Boss brings both seasons to Prime Video.
Expect a blend of outrageous stories, psychological twists, dark comedy, and action-packed thrills. Here’s more on what’s premiering this month.
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THE RUNAROUNDS (SEASON ONE)
The Runarounds follows a group of recent high school graduates from Wilmington, North Carolina, who come together the summer after graduation to form a rock band, united by their shared love of music and near-impossible dream of stardom.
Over the course of one unforgettable summer, they throw themselves into the pursuit of their big break—falling in love, getting into trouble, and building the kind of bonds that feel like family along the way.
With original music, romantic entanglements, and the raw highs and lows of coming-of-age, The Runarounds captures the rush of risking everything at the edge of adulthood to chase your dreams.
Air Date: Monday, Sept. 1, 2025
THE GIRLFRIEND (LIMITED SERIES)
Based on Michelle Frances’ novel of the same name, this 6 part limited series follows Laura (Robin Wright, House of Cards), a woman who seemingly has it all: a glittering career, a loving husband, and her precious son, Daniel (Laurie Davidson, The Sandman).
Her perfect life begins to unravel when Daniel brings home Cherry (Olivia Cooke, House of the Dragon), a girlfriend who changes everything.
After a tense introduction, Laura becomes convinced Cherry is hiding something. Is she a manipulative social climber, or is Laura just paranoid?
The truth is a matter of perspective.
Air Date: Wednesday, Sept. 10, 2025.
HELLUVA BOSS (SEASONS ONE & TWO)
Set in Hell, Helluva Boss is an animated comedy series, originally released on YouTube, that follows the hell-born imp Blitzo (the “o” is silent). Blitzo is the eccentric leader of I.M.P. (Immediate Murder Professionals), a small, chaotic assassination business that is able to run thanks to a magic grimoire, and a complicated situationship with the demon prince Stolas.
Alongside his equally chaotic ragtag crew – Moxxie, a by-the-books marksman; Millie, a fiery and skilled assassin; and Loona, their snarky, hellbound receptionist – Blitzo takes on contracts to kill targets in the human world.
Balancing their work with personal lives, the team constantly finds themselves in absurd, violent and darkly comedic situations.
Air Date: Wednesday, Sept. 10, 2025.
GEN V (SEASON 2)
School is back in session. As the rest of America adjusts to Homelander’s iron fist, back at Godolkin University, the mysterious new Dean preaches a curriculum that promises to make students more powerful than ever.
Cate and Sam are celebrated heroes, while Marie, Jordan, and Emma reluctantly return to college, burdened by months of trauma and loss.
But parties and classes are hard to care about with war brewing between Humans and Supes, both on and off campus.
The gang learns of a secret program that goes back to the founding of Godolkin University that may have larger implications than they realize. And, somehow, Marie is a part of it.
Air Date: Wednesday, Sept. 17, 2025.
HOTEL COSTIERA (SEASON ONE)
Daniel De Luca (Jesse Williams) is a half Italian former U.S. marine who returns to Italy, the land of his childhood, as a fixer in one of the world’s most luxurious hotels, located on the spectacular coastline of Positano.
In addition to dealing with the hotel’s wealthy guests’ problems, Daniel is also on the trail of Alice, one of the owner’s daughters who disappeared a month earlier.
Daniel must do everything he can to bring her home, but facing those who kidnapped the girl will be more challenging than any problem Daniel has ever faced.
Air Date: Wednesday, Sept. 24, 2025.
